Excitotoxicity and ALS: New therapy targets an old mechanism.

Authors :: Smith HL
Chaytow H
Gillingwater TH
Source :: Cell reports. Medicine [Cell Rep Med] 2024 Feb 20; Vol. 5 (2), pp. 101423.
Publication Year :: 2024
Abstract: Excitotoxicity-induced cell death in motor neurons is a major therapeutic target for amyotrophic lateral sclerosis (ALS). Yan et al. <superscript>1</superscript> present a novel compound to specifically disrupt extra-synaptic NMDAR complexes, extending the lifespan of the SOD1 <superscript>G93A</superscript> ALS mouse and ameliorating cell death.<br />Competing Interests: Declaration of interests T.H.G. has provided consultancy services for Roche and Novartis.<br /> (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)