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CENPA promotes glutamine metabolism and tumor progression by up-regulating SLC38A1 in endometrial cancer.
- Source :
-
Cellular signalling [Cell Signal] 2024 May; Vol. 117, pp. 111110. Date of Electronic Publication: 2024 Feb 20. - Publication Year :
- 2024
-
Abstract
- Glutamine addiction is a significant hallmark of metabolic reprogramming in tumors and is crucial to the progression of cancer. Nevertheless, the regulatory mechanisms of glutamine metabolism in endometrial cancer (EC) remains elusive. In this research, we found that elevated expression of CENPA and solute carrier family 38 member 1 (SLC38A1) were firmly associated with worse clinical stage and unfavorable outcomes in EC patients. In addition, ectopic overexpression or silencing of CENPA could either enhance or diminish glutamine metabolism and tumor progression in EC. Mechanistically, CENPA directly regulated the transcriptional activity of the target gene, SLC38A1, leading to enhanced glutamine uptake and metabolism, thereby promoting EC progression. Notably, a prognostic model utilizing the expression levels of CENPA and SLC38A1 genes independently emerged as a prognostic factor for EC. More importantly, CENPA and SLC38A1 were significantly elevated and positively correlated, as well as indicative of poor prognosis in multiple cancers. In brief, our study confirmed that CENPA is a critical transcription factor involved in glutamine metabolism and tumor progression through modulating SLC38A1. This revelation suggests that targeting CENPA could be an appealing therapeutic approach to address pan-cancer glutamine addiction.<br />Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.<br /> (Copyright © 2024. Published by Elsevier Inc.)
- Subjects :
- Female
Humans
Cell Cycle Proteins metabolism
Cell Proliferation
Histones
Transcription Factors metabolism
Amino Acid Transport System A genetics
Amino Acid Transport System A metabolism
Endometrial Neoplasms metabolism
Endometrial Neoplasms pathology
Glutamine metabolism
Centromere Protein A metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3913
- Volume :
- 117
- Database :
- MEDLINE
- Journal :
- Cellular signalling
- Publication Type :
- Academic Journal
- Accession number :
- 38382691
- Full Text :
- https://doi.org/10.1016/j.cellsig.2024.111110