Five new sesquiterpenoids isolated from Dictamnus dasycarpus Turcz.

Authors :: Sun Y
Liu Y
Wang SY
Yang X
Wu JT
Pan J
Hao ZC
Guan W
Algradi AM
Xu ZP
Zhou YY
Lv SW
Kuang HX
Yang BY
Source :: Fitoterapia [Fitoterapia] 2024 Apr; Vol. 174, pp. 105874. Date of Electronic Publication: 2024 Feb 27.
Publication Year :: 2024
Abstract: Five new sesquiterpenoids, dictamtrinorguaianols E and F (1-2), and dictameudesmnosides F, G, and H (3-5), along with seven known sesquiterpenoids (6-12) were isolated from Dictamnus dasycarpus Turcz. The structures of all new compounds were characterized by spectroscopic methods, including UV, IR, HR-ESI-MS, and 1D and 2D NMR. The In-vitro anti-proliferative activities of all the compounds against two human cancer cell lines (SW982 and A549) were evaluated by CCK-8 assay. Compounds 1 and 4 showed medium anti-proliferative activity against SW982 cells, with IC <subscript>50</subscript> values of 3.49 ± 0.10 and 6.42 ± 1.23 μM, respectively. Additionally, compounds 2, 7, and 8 exhibited medium anti-proliferative activity against A549 cells, with IC50 values ranging from 0.80 ± 0.05 to 6.60 ± 0.46 μM.<br />Competing Interests: Declaration of competing interest Ye Sun and Yan Liu contributed equally to this study. No potential conflict of interest was reported by the authors.<br /> (Copyright © 2024. Published by Elsevier B.V.)