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A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy.
- Source :
-
Current protein & peptide science [Curr Protein Pept Sci] 2024; Vol. 25 (7), pp. 539-552. - Publication Year :
- 2024
-
Abstract
- Gastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive kinase activity and promoting oncogenesis. ALK mutations are less common but can also result in the activation of ALK signaling pathways. Targeted therapies for ALK variations in gastric adenocarcinoma have been developed, including ALK inhibitors that have shown promising results in pre-clinical studies. Future studies are needed to elucidate the ALK role in gastric cancer and to identify predictive biomarkers to improve patient selection for targeted therapy. Overall, ALK alterations are a relevant biomarker for gastric adenocarcinoma treatment and targeted therapies for ALK may improve patients' overall survival.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Subjects :
- Humans
Adenocarcinoma genetics
Adenocarcinoma drug therapy
Adenocarcinoma pathology
Gene Rearrangement
Signal Transduction
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Anaplastic Lymphoma Kinase genetics
Anaplastic Lymphoma Kinase antagonists & inhibitors
Anaplastic Lymphoma Kinase metabolism
Stomach Neoplasms genetics
Stomach Neoplasms drug therapy
Stomach Neoplasms pathology
Molecular Targeted Therapy methods
Mutation
Protein Kinase Inhibitors pharmacology
Protein Kinase Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1875-5550
- Volume :
- 25
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Current protein & peptide science
- Publication Type :
- Academic Journal
- Accession number :
- 38424421
- Full Text :
- https://doi.org/10.2174/0113892037291318240130103348