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Severe Acute Interstitial Nephritis Induced by α-glucosidase Inhibitor Miglitol in an Elderly Patient with Type 2 Diabetic Nephropathy.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2024 Oct 15; Vol. 63 (20), pp. 2827-2831. Date of Electronic Publication: 2024 Mar 04. - Publication Year :
- 2024
-
Abstract
- A 79-year-old male patient with type 2 diabetic nephropathy and hypertension was admitted to our hospital because of acute kidney injury with significantly elevated serum creatinine (8.12 mg/dL) and urinary β2-microglobulin (β2MG, 31,748 μg/L) levels. α-glucosidase inhibitor (α-GI) miglitol, started two weeks prior to presentation, was discontinued because drug-induced acute interstitial nephritis (AIN) was suspected. Renal biopsy revealed AIN and diabetic nephropathy. The drug-induced lymphocyte stimulation test for miglitol was also positive. After the discontinuation of miglitol, the urinary β2MG levels decreased to the normal range. This case raises the possibility that α-GI miglitol can worsen the renal function in patients with underlying renal dysfunction.
- Subjects :
- Humans
Male
Aged
Severity of Illness Index
Acute Kidney Injury chemically induced
Acute Kidney Injury diagnosis
Acute Disease
Nephritis, Interstitial chemically induced
Nephritis, Interstitial diagnosis
Glycoside Hydrolase Inhibitors adverse effects
Glycoside Hydrolase Inhibitors therapeutic use
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 complications
Diabetic Nephropathies diagnosis
1-Deoxynojirimycin analogs & derivatives
1-Deoxynojirimycin adverse effects
1-Deoxynojirimycin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 63
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 38432957
- Full Text :
- https://doi.org/10.2169/internalmedicine.3156-23