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How we use angiopoietin-2 in the diagnosis and management of vascular anomalies.
- Source :
-
Pediatric blood & cancer [Pediatr Blood Cancer] 2024 May; Vol. 71 (5), pp. e30921. Date of Electronic Publication: 2024 Mar 04. - Publication Year :
- 2024
-
Abstract
- The diagnosis of vascular anomalies remains challenging due to significant clinical heterogeneity and uncertain etiology. Evaluation using biopsy and/or genetic testing for somatic variants is invasive, expensive, and prone to sampling error. There is great need for noninvasive and easily measured blood laboratory biomarkers that can aid not only in diagnosis, but also management of treatments for vascular anomalies. Angiopoietin-2, a circulating blood angiogenic factor, is highly elevated in patients with kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon and kaposiform lymphangiomatosis. Here, we describe our clinical experience using serum angiopoietin-2 as a biomarker for diagnosis and monitoring response to treatment.<br /> (© 2024 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.)
- Subjects :
- Humans
Biomarkers blood
Hemangioendothelioma blood
Hemangioendothelioma diagnosis
Hemangioendothelioma therapy
Kasabach-Merritt Syndrome blood
Kasabach-Merritt Syndrome diagnosis
Kasabach-Merritt Syndrome therapy
Angiopoietin-2 blood
Vascular Malformations blood
Vascular Malformations diagnosis
Vascular Malformations therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1545-5017
- Volume :
- 71
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pediatric blood & cancer
- Publication Type :
- Academic Journal
- Accession number :
- 38439088
- Full Text :
- https://doi.org/10.1002/pbc.30921