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Ameliorative effects of zinc and vitamin E against phthalates-induced reproductive toxicity in male rats.
- Source :
-
Environmental toxicology [Environ Toxicol] 2024 Jun; Vol. 39 (6), pp. 3330-3340. Date of Electronic Publication: 2024 Mar 05. - Publication Year :
- 2024
-
Abstract
- Objective: Phthalates (PEs) could cause reproductive harm to males. A mixture of three widely used PEs (MPEs) was used to investigate the ameliorative effects of zinc (Zn) and vitamin E (VE) against male reproductive toxicity.<br />Methods: Fifty male SD rats were randomly divided into five groups (n = 10). Rats in MPEs group were orally treated with 160 mg/kg/d MPEs, while rats in MPEs combined Zn and/or VE groups were treated with 160 mg/kg/d MPEs plus 25 mg/kg/d Zn and/or 25 mg/kg/d VE. After intervention for 70 days, it's was measured of male reproductive organs' weight, histopathological observation of sperms and testes, serum hormones, PIWI proteins and steroidogenic proteins.<br />Results: Compared with control, anogenital distance, testes weight, epididymides weight, and sex hormones were significantly decreased, while the sperm malformation rate was markedly increased in MPEs group (p < .05); the testicular tissues were injured in MPEs group with disordered and decreased spermatids, and arrested spermatogenesis. PIWIL1, PIWIL2, StAR, CYP11A1 and CYP19A1 were down-regulated in MPEs group (p < .05). However, the alterations of these parameters were restored in MPEs combined Zn and/or VE groups (p < .05).<br />Conclusion: Zn and/or VE improved steroid hormone metabolism, and inhibited MPEs' male reproductive toxicity.<br /> (© 2024 Wiley Periodicals LLC.)
Details
- Language :
- English
- ISSN :
- 1522-7278
- Volume :
- 39
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Environmental toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 38440903
- Full Text :
- https://doi.org/10.1002/tox.24191