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Multitasking functions of bacterial extracellular DNA in biofilms.

Authors :
Sharma DK
Rajpurohit YS
Source :
Journal of bacteriology [J Bacteriol] 2024 Apr 18; Vol. 206 (4), pp. e0000624. Date of Electronic Publication: 2024 Mar 06.
Publication Year :
2024

Abstract

Bacterial biofilms are intricate ecosystems of microbial communities that adhere to various surfaces and are enveloped by an extracellular matrix composed of polymeric substances. Within the context of bacterial biofilms, extracellular DNA (eDNA) originates from cell lysis or is actively secreted, where it exerts a significant influence on the formation, stability, and resistance of biofilms to environmental stressors. The exploration of eDNA within bacterial biofilms holds paramount importance in research, with far-reaching implications for both human health and the environment. An enhanced understanding of the functions of eDNA in biofilm formation and antibiotic resistance could inspire the development of strategies to combat biofilm-related infections and improve the management of antibiotic resistance. This comprehensive review encapsulates the latest discoveries concerning eDNA, encompassing its origins, functions within bacterial biofilms, and significance in bacterial pathogenesis.<br />Competing Interests: The authors declare no conflict of interest.

Details

Language :
English
ISSN :
1098-5530
Volume :
206
Issue :
4
Database :
MEDLINE
Journal :
Journal of bacteriology
Publication Type :
Academic Journal
Accession number :
38445859
Full Text :
https://doi.org/10.1128/jb.00006-24