Back to Search
Start Over
Nationwide data from comprehensive genomic profiling assays for detecting driver oncogenes in non-small cell lung cancer.
- Source :
-
Cancer science [Cancer Sci] 2024 May; Vol. 115 (5), pp. 1656-1664. Date of Electronic Publication: 2024 Mar 07. - Publication Year :
- 2024
-
Abstract
- Driver oncogenes are investigated upfront at diagnosis using multi-CDx systems with next-generation sequencing techniques or multiplex reverse-transcriptase polymerase chain reaction assays. Additionally, from 2019, comprehensive genomic profiling (CGP) assays have been available in Japan for patients with advanced solid tumors who had completed or were expected to complete standard chemotherapy. These assays are expected to comprehensively detect the driver oncogenes, especially for patients with non-small cell lung cancer (NSCLC). However, there are no reports of nationwide research on the detection of driver oncogenes in patients with advanced NSCLC who undergo CGP assays, especially in those with undetected driver oncogenes at diagnosis. In this study, we investigated the proportion of driver oncogenes detected in patients with advanced NSCLC with undetectable driver oncogenes at initial diagnosis and in all patients with advanced NSCLC who underwent CGP assays. We retrospectively analyzed data from 986 patients with advanced NSCLC who underwent CGP assays between August 2019 and March 2022, using the Center for Cancer Genomics and Advanced Therapeutics database. The proportion of driver oncogenes newly detected in patients with NSCLC who tested negative for driver oncogenes at diagnosis and in all patients with NSCLC were investigated. Driver oncogenes were detected in 451 patients (45.7%). EGFR was the most common (16.5%), followed by KRAS (14.5%). Among the 330 patients with undetected EGFR, ALK, ROS1, and BRAF V600E mutations at diagnosis, 81 patients (24.5%) had newly identified driver oncogenes. CGP assays could be useful to identify driver oncogenes in patients with advanced NSCLC, including those initially undetected, facilitating personalized treatment.<br /> (© 2024 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.)
- Subjects :
- Humans
Male
Female
Aged
Middle Aged
Retrospective Studies
Japan
High-Throughput Nucleotide Sequencing methods
ErbB Receptors genetics
Aged, 80 and over
Adult
Proto-Oncogene Proteins B-raf genetics
Proto-Oncogene Proteins p21(ras) genetics
Proto-Oncogene Proteins genetics
Gene Expression Profiling methods
Genomics methods
Protein-Tyrosine Kinases genetics
Receptor Protein-Tyrosine Kinases genetics
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Non-Small-Cell Lung pathology
Lung Neoplasms genetics
Lung Neoplasms pathology
Oncogenes genetics
Mutation
Anaplastic Lymphoma Kinase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7006
- Volume :
- 115
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer science
- Publication Type :
- Academic Journal
- Accession number :
- 38450844
- Full Text :
- https://doi.org/10.1111/cas.16130