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Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery.
- Source :
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Surgery today [Surg Today] 2024 Sep; Vol. 54 (9), pp. 995-1004. Date of Electronic Publication: 2024 Mar 07. - Publication Year :
- 2024
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Abstract
- Purpose: Radiation pneumonitis (RP) is an obstacle for patients after surgery following induction chemoradiotherapy for locally advanced non-small cell lung cancer (LA-NSCLC). We performed a comparative analysis of the association between clinicopathological factors, including the neutrophil-to-lymphocyte ratio (NLR) and prognosis, in LA-NSCLC patients with or without RP during induction chemoradiotherapy followed by surgery.<br />Methods: The subjects of this analysis were 168 patients undergoing trimodality therapy for LA-NSCLC between January, 1999 and May, 2019. Patients were divided into two groups: the RP group (nā=ā41) and the non-RP group (nā=ā127). We compared the clinicopathological factors including the NLR between the groups and analyzed the association between the NLR and prognosis.<br />Results: The RP group had more patients with tumors located in the lower lobe, more bilobar resections, shorter operative times, no implementation of postoperative adjuvant chemotherapy, and a higher postoperative NLR than the non-RP group. There were no significant differences in serious postoperative complications and the prognosis. Patients with a low postoperative NLR had a significantly better prognosis in the non-RP group, and a trend toward a better prognosis even in the RP group.<br />Conclusion: Postoperative NLR may be a useful prognostic factor, even for patients who suffer RP after trimodality therapy for LA-NSCLC.<br /> (© 2024. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.)
Details
- Language :
- English
- ISSN :
- 1436-2813
- Volume :
- 54
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Surgery today
- Publication Type :
- Academic Journal
- Accession number :
- 38451313
- Full Text :
- https://doi.org/10.1007/s00595-024-02816-y