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Hepatocellular Carcinoma LINC01116 Outcompetes T Cells for Linoleic Acid and Accelerates Tumor Progression.
- Source :
-
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Jun; Vol. 11 (21), pp. e2400676. Date of Electronic Publication: 2024 Mar 09. - Publication Year :
- 2024
-
Abstract
- Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a highly immunosuppressive tumor microenvironment and a typical pattern of disturbances in hepatic lipid metabolism. Long non-coding RNAs are shown to play an important role in the regulation of gene expression, but much remains unknown between tumor microenvironment and lipid metabolism as a bridging molecule. Here, long intergenic nonprotein coding RNA 01116 (LINC01116) acts as this molecular which is frequently upregulated in HCC patients and associated with HCC progression in vitro and in vivo is identified. Mechanistically, LINC01116 stabilizes EWS RNA-binding protein 1 (EWSR1) by preventing RAD18 E3 Ubiquitin Protein Ligase (RAD18) -mediated ubiquitination. The enhanced EWSR1 protein upregulates peroxisome proliferator activated receptor alpha (PPARA) and fatty acid binding protein1 (FABP1) expression, a long-chain fatty acid (LCFA) transporter, and thus cancer cells outcompete T cells for LCFAs, especially linoleic acid, for seeding their own growth, leading to T cell malfunction and HCC malignant progression. In a preclinical animal model, the blockade of LINC01116 leads to enhanced efficacy of anti-PD1 treatment accompanied by increased cytotoxic T cell and decreased exhausted T cell infiltration. Collectively, LINC01116 is an immunometabolic lncRNA and the LINC01116-EWSR1-PPARA-FABP1 axis may be targetable for cancer immunotherapy.<br /> (© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)
- Subjects :
- Humans
Animals
Mice
Tumor Microenvironment genetics
Tumor Microenvironment immunology
Disease Models, Animal
Cell Line, Tumor
Gene Expression Regulation, Neoplastic genetics
Carcinoma, Hepatocellular genetics
Carcinoma, Hepatocellular pathology
Carcinoma, Hepatocellular metabolism
Carcinoma, Hepatocellular immunology
Liver Neoplasms genetics
Liver Neoplasms pathology
Liver Neoplasms metabolism
Liver Neoplasms immunology
RNA, Long Noncoding genetics
RNA, Long Noncoding metabolism
Disease Progression
Linoleic Acid metabolism
T-Lymphocytes immunology
T-Lymphocytes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2198-3844
- Volume :
- 11
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Advanced science (Weinheim, Baden-Wurttemberg, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 38460179
- Full Text :
- https://doi.org/10.1002/advs.202400676