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From mice to men: An assessment of preclinical model systems for the study of vitiligo.

Authors :
Wu W
Wang X
He K
Li C
Li S
Source :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2024 May; Vol. 262, pp. 110171. Date of Electronic Publication: 2024 Mar 08.
Publication Year :
2024

Abstract

Vitiligo is an autoimmune skin disease of multiple etiology, for which there is no complete cure. This chronic depigmentation is characterized by epidermal melanocyte loss, and causes disfigurement and significant psychosocial distress. Mouse models have been extensively employed to further our understanding of complex disease mechanisms in vitiligo, as well as to provide a preclinical platform for clinical interventional research on potential treatment strategies in humans. The current mouse models can be categorized into three groups: spontaneous mouse models, induced mouse models, and transgenic mice. Despite their limitations, these models allow us to understand the pathology processes of vitiligo at molecule, cell, tissue, organ, and system levels, and have been used to test prospective drugs. In this review, we comprehensively evaluate existing murine systems of vitiligo and elucidate their respective characteristics, aiming to offer a panorama for researchers to select the appropriate mouse models for their study.<br />Competing Interests: Declaration of competing interest The authors declare no conflict of interest.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1521-7035
Volume :
262
Database :
MEDLINE
Journal :
Clinical immunology (Orlando, Fla.)
Publication Type :
Academic Journal
Accession number :
38462156
Full Text :
https://doi.org/10.1016/j.clim.2024.110171