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Clinical evolution of antisynthetase syndrome-associated interstitial lung disease after COVID-19 in a man with Klinefelter syndrome: A case report.
- Source :
-
World journal of clinical cases [World J Clin Cases] 2024 Feb 26; Vol. 12 (6), pp. 1144-1149. - Publication Year :
- 2024
-
Abstract
- Background: This study presents a case of rapidly developing respiratory failure due to antisynthetase syndrome (AS) following coronavirus disease 2019 (COVID-19) in a 33-year-old man diagnosed with Klinefelter syndrome (KS).<br />Case Summary: A 33-year-old man with a diagnosis of KS was admitted to the Department of Pulmonary and Critical Care Medicine of a tertiary hospital in China for fever and shortness of breath 2 wk after the onset of COVID-19. Computed tomography of both lungs revealed diffuse multiple patchy heightened shadows in both lungs, accompanied by signs of partial bronchial inflation. Metagenomic next-generation sequencing of the bronchoalveolar lavage fluid suggested absence of pathogen. A biopsy specimen revealed organizing pneumonia with alveolar septal thickening. Additionally, extensive auto-antibody tests showed strong positivity for anti-SSA, anti-SSB, anti-Jo-1, and anti-Ro-52. Following multidisciplinary discussions, the patient received a final diagnosis of AS, leading to rapidly progressing respiratory failure.<br />Conclusion: This study underscores the clinical progression of AS-associated interstitial lung disease subsequent to viral infections such as COVID-19 in patients diagnosed with KS.<br />Competing Interests: Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.<br /> (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 2307-8960
- Volume :
- 12
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- World journal of clinical cases
- Publication Type :
- Report
- Accession number :
- 38464923
- Full Text :
- https://doi.org/10.12998/wjcc.v12.i6.1144