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Neurocognitive outcome and associated factors in long-term, adult survivors of childhood acute lymphoblastic leukemia, treated without cranial radiation therapy.
- Source :
-
Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2024 Jul; Vol. 30 (6), pp. 523-532. Date of Electronic Publication: 2024 Mar 11. - Publication Year :
- 2024
-
Abstract
- Objective: There is limited research on neurocognitive outcome and associated risk factors in long-term, adult survivors of childhood acute lymphoblastic leukemia (ALL), without treatment of cranial radiation therapy. Moreover, the impact of fatigue severity and pain interference on neurocognition has received little attention. In this cross-sectional study, we examined neurocognitive outcome and associated factors in this population.<br />Method: Intellectual abilities, verbal learning/memory, processing speed, attention, and executive functions were compared to normative means/medians with one sample t tests or Wilcoxon signed-rank tests. Associations with risk factors, fatigue severity, and pain interference were analyzed with linear regressions.<br />Results: Long-term, adult survivors of childhood ALL ( N = 53, 51% females, mean age = 24.4 years, SD = 4.4, mean = 14.7 years post-diagnosis, SD = 3.4) demonstrated above average intellectual abilities, but performed below average in attention, inhibition, processing speed, and shifting ( p < 0.001). Executive functioning complaints were significantly higher than normative means, and positively associated with fatigue ( p < 0.001). There was no interaction between sex and fatigue and no neurocognitive impairments were associated with pain interference, risk group, age at diagnosis, or sex.<br />Conclusions: Long-term, adult survivors of ALL treated without cranial radiation therapy, demonstrate domain-specific performance-based neurocognitive impairments. However, continued research on the neurocognitive outcome in this population as they age will be important in the coming years. Executive functioning complaints were frequently in the clinical range, and often accompanied by fatigue. This suggests a need for cognitive rehabilitation programs.
- Subjects :
- Humans
Female
Male
Adult
Young Adult
Cross-Sectional Studies
Adolescent
Fatigue etiology
Cognitive Dysfunction etiology
Cognitive Dysfunction physiopathology
Attention physiology
Neuropsychological Tests
Intelligence physiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma radiotherapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma complications
Cancer Survivors
Executive Function physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1469-7661
- Volume :
- 30
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of the International Neuropsychological Society : JINS
- Publication Type :
- Academic Journal
- Accession number :
- 38465668
- Full Text :
- https://doi.org/10.1017/S1355617724000080