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Tyrosine kinase inhibitors in patients with advanced anaplastic thyroid cancer: an effective analysis based on real-world retrospective studies.
- Source :
-
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Feb 26; Vol. 15, pp. 1345203. Date of Electronic Publication: 2024 Feb 26 (Print Publication: 2024). - Publication Year :
- 2024
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Abstract
- Background: Tyrosine kinase inhibitors (TKIs) contribute to the treatment of patients with anaplastic thyroid cancer (ATC). Although prospective clinical studies of TKIs exhibit limited efficacy, whether ATC patients benefit from TKI treatment in real-world clinical practice may enlighten future explorations. Therefore, we conducted this effective analysis based on real-world retrospective studies to illustrate the efficacy of TKI treatment in ATC patients.<br />Methods: We systematically searched the online databases on September 03, 2023. Survival curves were collected and reconstructed to summarize the pooled curves. Responses were analyzed by using the "meta" package. The primary endpoints were progression-free survival (PFS), overall survival (OS), objective response rate (ORR), and disease control rate (DCR).<br />Results: 12 studies involving 227 patients were enrolled in the study. Therapeutic strategies included: anlotinib, lenvatinib, dabrafenib plus trametinib, vemurafenib, pembrolizumab plus dabrafenib and trametinib, pembrolizumab plus lenvatinib, pembrolizumab plus trametinib, and sorafenib. The pooled median OS and PFS were 6.37 months (95% CI 4.19-10.33) and 5.50 months (95% CI 2.17-12.03). The integrated ORR and DCR were 32% (95% CI 23%-41%) and 40% (95% CI 12%-74%).<br />Conclusion: In real-world clinical practice, ATC patients could benefit from TKI therapy. In future studies, more basic experiments and clinical explorations are needed to enhance the effects of TKIs in the treatment of patients with ATC.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Kuang, Zhang, Lin, Fu, Cao and Wang.)
- Subjects :
- Humans
Progression-Free Survival
Retrospective Studies
Thyroid Carcinoma, Anaplastic drug therapy
Thyroid Carcinoma, Anaplastic mortality
Thyroid Carcinoma, Anaplastic pathology
Thyroid Neoplasms drug therapy
Thyroid Neoplasms pathology
Thyroid Neoplasms mortality
Tyrosine Kinase Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1664-2392
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Frontiers in endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 38469143
- Full Text :
- https://doi.org/10.3389/fendo.2024.1345203