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Biphenotypic lung carcinoma with coexpression of TTF-1 and ΔNP63/P40 within most of the same individual cells: a further case confirming poor prognosis and a review of literature.
- Source :
-
Pathologica [Pathologica] 2024 Feb; Vol. 116 (1), pp. 13-21. - Publication Year :
- 2024
-
Abstract
- The WHO Classification of Tumors, Thoracic Tumors, 5th edition, has outlined the use of TTF-1 and ΔNP63/P40 to discriminate between adenocarcinoma and squamous cell carcinoma. In 2015, the first description of a rare non-small cell lung carcinoma featuring co-expression of glandular and squamous differentiation within most of the same individual tumor cells was reported on, with ultrastructural and molecular demonstration of such a biphenotypic differentiation. We herein describe an additional case of this rare tumor entity, which is confirmed to be an aggressive neoplasm despite potential targets of therapy.<br /> (Copyright © 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.)
Details
- Language :
- English
- ISSN :
- 1591-951X
- Volume :
- 116
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pathologica
- Publication Type :
- Academic Journal
- Accession number :
- 38482671
- Full Text :
- https://doi.org/10.32074/1591-951X-957