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Vinylogous and stereoselective domino synthesis of pyrano[2,3- c ]pyrroles from alkylidene meldrum's acids.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2024 Apr 17; Vol. 22 (15), pp. 2948-2952. Date of Electronic Publication: 2024 Apr 17. - Publication Year :
- 2024
-
Abstract
- A domino Vinylogous aza-Michael-Aldol-Cyclocondensation (aza-VMAC) reaction was achieved with a series of alkylidene Meldrum's acid derivatives under simple operational conditions paving the way to novel pyrano[2,3- c ]pyrroles in an excellent diasteroselectivity (>96 : 4), encompassing the relative control of three contiguous stereocenters.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 22
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38482880
- Full Text :
- https://doi.org/10.1039/d4ob00233d