Temporal patterning of the vertebrate developing neural tube.

The chronologically ordered generation of distinct cell types is essential for the establishment of neuronal diversity and the formation of neuronal circuits. Recently, single-cell transcriptomic analyses of various areas of the developing vertebrate nervous system have provided evidence for the existence of a shared temporal patterning program that partitions neurons based on the timing of neurogenesis. In this review, I summarize the findings that lead to the proposal of this shared temporal program before focusing on the developing spinal cord to discuss how temporal patterning in general and this program specifically contributes to the ordered formation of neuronal circuits.
Competing Interests: Declaration of Competing Interest I hereby declare that I do not have any conflicts of interest. Work in the Sagner Lab is supported by funding from the Deutsche Forschungsgemeinschaft (German Research Foundation — Projektnummer 455354162) and the Interdisciplinary Centre for Clinical Research of the FAU Erlangen-Nürnberg (IZKF – E36). The funders had no role in preparation of the manuscript or the decision to publish.
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