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Choroid plexus calcifications are not associated with putative markers of glymphatic dysfunction: A population study in middle-aged and older adults.
- Source :
-
The neuroradiology journal [Neuroradiol J] 2024 Jun; Vol. 37 (3), pp. 342-350. Date of Electronic Publication: 2024 Mar 15. - Publication Year :
- 2024
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Abstract
- Background and Purpose: Recent studies have suggested an association between dysfunction of the choroid plexus and the glymphatic system. However, information is inconclusive. Following a population-based study design, we aimed to assess the association between choroid plexus calcifications (CPCs)-as a surrogate of choroid plexus dysfunction-and severity and progression of putative markers of glymphatic dysfunction, including white matter hyperintensities (WMH) of presumed vascular origin and abnormally enlarged basal ganglia perivascular spaces (BG-PVS).<br />Methods: This study recruited community-dwellers aged ≥40 years living in neighboring Ecuadorian villages. Participants who had baseline head CTs and brain MRIs were included in cross-sectional analyses and those who additional had follow-up MRIs (after a mean of 6.4 ± 1.5 years) were included in longitudinal analyses. Logistic and Poisson regression models, adjusted for demographics and cardiovascular risk factors, were fitted to assess associations between CPCs and WMH and enlarged BG-PVS severity and progression.<br />Results: A total of 590 individuals were included in the cross-sectional component of the study, and 215 in the longitudinal component. At baseline, 25% of participants had moderate-to-severe WMH and 27% had abnormally enlarged BG-PVS. At follow-up, 36% and 20% of participants had WMH and enlarged BG-PVS progression, respectively. Logistic regression models showed no significant differences between CPCs volumes stratified in quartiles and severity of WMH and enlarged BG-PVS. Poisson regression models showed no association between the exposure and WMH and enlarged BG-PVS progression. Baseline age remained significant in these models.<br />Conclusions: Choroid plexus calcifications are not associated with putative markers of glymphatic system dysfunction.<br />Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Subjects :
- Humans
Male
Female
Middle Aged
Cross-Sectional Studies
Aged
Longitudinal Studies
Ecuador
White Matter diagnostic imaging
White Matter pathology
Adult
Tomography, X-Ray Computed
Biomarkers
Choroid Plexus diagnostic imaging
Choroid Plexus pathology
Glymphatic System diagnostic imaging
Magnetic Resonance Imaging methods
Calcinosis diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2385-1996
- Volume :
- 37
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The neuroradiology journal
- Publication Type :
- Academic Journal
- Accession number :
- 38490679
- Full Text :
- https://doi.org/10.1177/19714009241240315