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An epidermal growth factor receptor compound mutation of L858R with S768I in advanced non-small-cell lung cancer: a case report.
- Source :
-
Journal of medical case reports [J Med Case Rep] 2024 Mar 18; Vol. 18 (1), pp. 118. Date of Electronic Publication: 2024 Mar 18. - Publication Year :
- 2024
-
Abstract
- Background: In the current treatment landscape for non-small cell lung cancers, epidermal growth factor receptor-tyrosine kinase inhibitors have emerged as a well-established treatment option for patients with advanced or metastatic disease. This is particularly true for those with commonly occurring epidermal growth factor receptor mutations. However, the therapeutic efficacy of these agents for so-called rare epidermal growth factor receptor mutations, and in particular those characterized by a high degree of complexity, such as double mutations, remains a subject of clinical uncertainty.<br />Case Presentation: In this context, we present the case of a 64-year-old man of Moroccan descent, a lifelong non-smoker, diagnosed with metastatic non-small cell lung cancer characterized by a complex epidermal growth factor receptor mutation encompassing L858R and S768I. The patient subsequently underwent afatinib-based treatment, showing notable clinical results. These included a remarkable overall survival of 51 months, with a median progression-free survival of more than 39 months.<br />Conclusions: This case report is a compelling testimony to the evolving therapeutic landscape of non-small cell lung cancers, providing valuable insight into the potential therapeutic efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors in the realm of rare and complex epidermal growth factor receptor mutations.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Middle Aged
Clinical Decision-Making
ErbB Receptors genetics
ErbB Receptors therapeutic use
Mutation
Protein Kinase Inhibitors therapeutic use
Tyrosine Kinase Inhibitors
Uncertainty
Male
Carcinoma, Non-Small-Cell Lung drug therapy
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Non-Small-Cell Lung pathology
Lung Neoplasms drug therapy
Lung Neoplasms genetics
Lung Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1752-1947
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of medical case reports
- Publication Type :
- Academic Journal
- Accession number :
- 38494473
- Full Text :
- https://doi.org/10.1186/s13256-024-04422-5