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A case of AA amyloidosis complicated by proliferating pilomatricoma and a review of the literature.
- Source :
-
The Journal of dermatology [J Dermatol] 2024 Oct; Vol. 51 (10), pp. 1360-1363. Date of Electronic Publication: 2024 Mar 25. - Publication Year :
- 2024
-
Abstract
- Although AA amyloidosis is primarily caused by inflammatory conditions, associations between AA amyloidosis and solid cancers have occasionally been described. Herein, we report the case of a 48-year-old man in whom resection of a proliferating pilomatricoma with deposition of AA amyloid resulted in remission of concomitant AA gastrointestinal amyloidosis. A rapidly growing, giant, reddish, ulcerated tumor measuring 16 × 13 cm in size was identified on the upper left arm on a visit to our hospital. Gastrointestinal AA amyloidosis was diagnosed from colorectal mucosal biopsy at the same time, and weight loss and profuse diarrhea were clinically evident. As treatment, the tumor was resected with a 10-mm surgical margin. Histologically, the tumor predominantly comprised a lobular proliferation of basophilic cells peripherally, filled with eosinophilic, cornified material and shadow cells with mitoses observed in basophilic cells. Specimens revealed eosinophilic, homogeneous deposits around tumor nests, which were confirmed as amyloid deposits by positive staining with Congo red stain. These deposits were immunohistochemically positive on staining with anti-serum amyloid A antibody. Collectively, proliferating pilomatricoma with AA amyloidosis was diagnosed. After tumor resection, chronic diarrhea resolved and no amyloid deposition was apparent in colorectal biopsy. It is important to remember that if amyloid deposition is present in a tumor, aggressive tumor excision may alleviate systemic amyloidosis.<br /> (© 2024 Japanese Dermatological Association.)
- Subjects :
- Humans
Male
Middle Aged
Serum Amyloid A Protein analysis
Serum Amyloid A Protein metabolism
Diarrhea etiology
Diarrhea pathology
Biopsy
Intestinal Mucosa pathology
Intestinal Mucosa surgery
Pilomatrixoma pathology
Pilomatrixoma diagnosis
Pilomatrixoma complications
Pilomatrixoma surgery
Skin Neoplasms pathology
Skin Neoplasms surgery
Skin Neoplasms diagnosis
Skin Neoplasms complications
Amyloidosis pathology
Amyloidosis diagnosis
Amyloidosis complications
Amyloidosis surgery
Hair Diseases pathology
Hair Diseases diagnosis
Hair Diseases complications
Hair Diseases surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1346-8138
- Volume :
- 51
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 38525822
- Full Text :
- https://doi.org/10.1111/1346-8138.17203