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The je ne sais quoi of 5-methylcytosine in messenger RNA.
- Source :
-
RNA (New York, N.Y.) [RNA] 2024 Apr 16; Vol. 30 (5), pp. 560-569. Date of Electronic Publication: 2024 Apr 16. - Publication Year :
- 2024
-
Abstract
- The potential presence of 5-methylcytosine as a sparse internal modification of mRNA was first raised in 1975, and a first map of the modification was also part of the epitranscriptomics "big bang" in 2012. Since then, the evidence for its presence in mRNA has firmed up, and initial insights have been gained into the molecular function and broader biological relevance of 5-methylcytosine when present in mRNA. Here, we summarize the status quo of the field, outline some of its current challenges, and suggest how to address them in future work.<br /> (© 2024 Guarnacci and Preiss; Published by Cold Spring Harbor Laboratory Press for the RNA Society.)
- Subjects :
- RNA, Messenger genetics
5-Methylcytosine
RNA
Subjects
Details
- Language :
- English
- ISSN :
- 1469-9001
- Volume :
- 30
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- RNA (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 38531644
- Full Text :
- https://doi.org/10.1261/rna.079982.124