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Expression of Concern: Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells through mitochondrial reactive oxygen species-dependent JNK and endothelial nitric oxide synthase activation and overrides imatinib resistance.
- Source :
-
Cancer science [Cancer Sci] 2024 Jun; Vol. 115 (6), pp. 2086. Date of Electronic Publication: 2024 Mar 27. - Publication Year :
- 2024
- Subjects :
- Humans
Plant Leaves
Eugenol pharmacology
Eugenol analogs & derivatives
Cell Line, Tumor
Reactive Oxygen Species metabolism
Imatinib Mesylate pharmacology
Apoptosis drug effects
Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics
Drug Resistance, Neoplasm
Mitochondria metabolism
Mitochondria drug effects
Nitric Oxide Synthase Type III metabolism
Piper betle chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7006
- Volume :
- 115
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cancer science
- Publication Type :
- Editorial & Opinion
- Accession number :
- 38538295
- Full Text :
- https://doi.org/10.1111/cas.16155