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Design of Nanodrug Delivery Systems for Tumor Bone Metastasis.
- Source :
-
Current pharmaceutical design [Curr Pharm Des] 2024; Vol. 30 (15), pp. 1136-1148. - Publication Year :
- 2024
-
Abstract
- Tumor metastasis is a complex process that is controlled at the molecular level by numerous cytokines. Primary breast and prostate tumors most commonly metastasize to bone, and the development of increasingly accurate targeted nanocarrier systems has become a research focus for more effective anti-bone metastasis therapy. This review summarizes the molecular mechanisms of bone metastasis and the principles and methods for designing bone-targeted nanocarriers and then provides an in-depth review of bone-targeted nanocarriers for the treatment of bone metastasis in the context of chemotherapy, photothermal therapy, gene therapy, and combination therapy. Furthermore, this review also discusses the treatment of metastatic and primary bone tumors, providing directions for the design of nanodelivery systems and future research.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Subjects :
- Humans
Animals
Drug Design
Nanoparticles chemistry
Nanoparticles administration & dosage
Drug Carriers chemistry
Bone Neoplasms secondary
Bone Neoplasms drug therapy
Drug Delivery Systems
Antineoplastic Agents pharmacology
Antineoplastic Agents administration & dosage
Antineoplastic Agents chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4286
- Volume :
- 30
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Current pharmaceutical design
- Publication Type :
- Academic Journal
- Accession number :
- 38551047
- Full Text :
- https://doi.org/10.2174/0113816128296883240320040636