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Self-emulsifying drug delivery systems (SEDDS) containing Cymbopogon citratus essential oil: Enhancing the stability and acaricide efficacy against Rhipicephalus (Boophilus) microplus.
- Source :
-
Veterinary parasitology [Vet Parasitol] 2024 Jun; Vol. 328, pp. 110171. Date of Electronic Publication: 2024 Mar 16. - Publication Year :
- 2024
-
Abstract
- The objectives of this study were to develop a self-emulsifying drug delivery system (SEDDS) to enhance the stability and efficacy of Cymbopogon citratus essential oil or lemongrass oil (LEO) against cattle tick larvae and engorged females. The system with the highest oil loading in SEDDS was composed of LEO (23.33%w/w), Tween 80: SGKH 4000 in a 2:1 ratio as surfactant (66.67%w/w), and propylene glycol as co-surfactant (10%w/w). The selected SEDDS-LEO has a particle size of 18.78 nm with a narrow size distribution (polydispersity index of 0.27). Notably, the stability of SEDDS was superior to that of the original oil, both during long-term storage and under accelerated conditions. SEDDS-LEO at oil concentrations ranging from 1.458% to 5.833% w/v showed a significantly higher percentage of egg-laying reduction against adult ticks compared with the original oil at the same concentrations (p < 0.05). Furthermore, SEDDS-LEO demonstrated greater larvicidal efficacy than the original oil, with lower LC <subscript>50</subscript> and LC <subscript>90</subscript> values of 0.91 mg/mL and 1.20 mg/mL, respectively, whereas the original oil's LC <subscript>50</subscript> and LC <subscript>90</subscript> values were 1.17 mg/mL and 1.74 mg/mL, respectively. Our findings indicate that SEDDS-LEO is a promising candidate for use as an acaricide in the control of tick populations in dairy cattle.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Female
Cattle
Larva drug effects
Plant Oils pharmacology
Plant Oils chemistry
Cattle Diseases parasitology
Cattle Diseases prevention & control
Cattle Diseases drug therapy
Emulsions chemistry
Drug Stability
Tick Infestations veterinary
Tick Infestations drug therapy
Tick Infestations prevention & control
Tick Infestations parasitology
Terpenes
Rhipicephalus drug effects
Cymbopogon chemistry
Oils, Volatile pharmacology
Oils, Volatile chemistry
Acaricides administration & dosage
Drug Delivery Systems
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2550
- Volume :
- 328
- Database :
- MEDLINE
- Journal :
- Veterinary parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 38552269
- Full Text :
- https://doi.org/10.1016/j.vetpar.2024.110171