Back to Search Start Over

Drug-Induced Anaphylaxis Uncommon in Mastocytosis: Findings From Two Large Cohorts.

Authors :
Beyens M
Sabato V
Ebo DG
Zaghmout T
Gülen T
Source :
The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2024 Jul; Vol. 12 (7), pp. 1850-1862.e1. Date of Electronic Publication: 2024 Mar 29.
Publication Year :
2024

Abstract

Background: Anaphylaxis is a common feature of patients with mastocytosis, particularly with Hymenoptera venoms. Hence, it is hypothesized that patients with mastocytosis may have an increased susceptibility to developing drug-induced anaphylaxis (DIA). Patients and medical practitioners are therefore concerned when there is a need to use various drugs. However, this issue has not been systematically investigated.<br />Objective: To investigate the prevalence and clinical characteristics of anaphylaxis to various types of drugs among patients with mastocytosis.<br />Methods: A retrospective study was conducted among 470 consecutive patients (18 years and older) with confirmed clonal mast cell diseases recruited from 2 independent mastocytosis reference centers. All patients underwent a comprehensive, individualized allergy workup with evaluation of the (self)reported drug hypersensitivity.<br />Results: The overall prevalence of DIA was 6.3%, accounting for one-third of the confirmed drug hypersensitivity reactions. Nonsteroidal anti-inflammatory drugs were the most common elicitors of DIA (56%), followed by perioperative agents (23%) and antibiotics (13%). Anaphylactic reactions were severe in most cases, with 43% of patients experiencing hypotensive syncope. All drug-related hypersensitivity reactions occurred before mastocytosis was diagnosed.<br />Conclusions: The prevalence of DIA in mastocytosis tends to be higher than in the general population, but is overall low. However, its severity is more pronounced. Our results suggest that patients with mastocytosis with a previous reaction to drugs should undergo a thorough allergy workup. Well-tolerated drugs can be further used without specific precautions.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
2213-2201
Volume :
12
Issue :
7
Database :
MEDLINE
Journal :
The journal of allergy and clinical immunology. In practice
Publication Type :
Academic Journal
Accession number :
38556047
Full Text :
https://doi.org/10.1016/j.jaip.2024.03.040