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Selective Mono-Defluorinative Cross-Coupling of Trifluoromethyl arenes via Multiphoton Photoredox Catalysis.

Authors :
Jia J
Zhumagazy S
Zhu C
Lee SC
Alsharif S
Yue H
Rueping M
Source :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Apr 22; Vol. 30 (23), pp. e202302927. Date of Electronic Publication: 2024 Apr 04.
Publication Year :
2024

Abstract

A new cross-coupling of trifluoromethyl arenes has been realized via multiphoton photoredox catalysis. Trifluoromethyl arenes were demonstrated to undergo selective mono-defluorinative alkylation under mild reaction conditions providing access to a series of valuable α,α-difluorobenzylic compounds. The reaction shows broad substrate scope and general functional group tolerance. In addition to the electron-deficient trifluoromethyl arenes that are easily reduced to the corresponding radical anion, more challenging electron-rich substrates were also successfully applied. Steady-State Stern-Volmer quenching studies indicated that the trifluoromethyl arenes were reduced by the multiphoton excited Ir-based photocatalyst.<br /> (© 2024 Wiley‐VCH GmbH.)

Details

Language :
English
ISSN :
1521-3765
Volume :
30
Issue :
23
Database :
MEDLINE
Journal :
Chemistry (Weinheim an der Bergstrasse, Germany)
Publication Type :
Academic Journal
Accession number :
38573029
Full Text :
https://doi.org/10.1002/chem.202302927