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Inter-laboratory comparison of routine autoantibody detection methods for autoimmune neuropathies and myasthenia gravis.
- Source :
-
Journal of neurology [J Neurol] 2024 Jul; Vol. 271 (7), pp. 4119-4130. Date of Electronic Publication: 2024 Apr 05. - Publication Year :
- 2024
-
Abstract
- Serological tests are important to detect autoantibodies (autoAbs) in patients with autoimmune neuropathies (AN) and myasthenia gravis (MG) as they are biomarkers for diagnosis, stratification, treatment selection, and monitoring. However, tests to detect autoAbs frequently lack proper standardization and results differ across diagnostic laboratories. We compared results for tests routinely performed in Spanish diagnostic laboratories to detect AN and MG autoAbs. In the Spanish Society of Immunology Autoimmunity Group national workshop, serum samples from 13 patients with AN or MG were tested for anti-ganglioside, anti-myelin-associated glycoprotein (MAG), anti-nicotinic acetylcholine receptor (AChR), and anti-muscle-specific kinase (MuSK) autoAbs using reference methods and were distributed for analysis to 27 participating laboratories using their routine methods. Overserved were inter-laboratory variability and worryingly low sensitivity, especially for anti-ganglioside immunoglobulin G and anti-MAG autoAb detection. This pilot study reflects autoAbs detection state of the art in AN and MG testing in leading diagnostic laboratories in Spain, highlighting the need for standardization prior to clinical use.<br /> (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
- Subjects :
- Humans
Pilot Projects
Spain
Male
Female
Autoimmune Diseases of the Nervous System diagnosis
Autoimmune Diseases of the Nervous System immunology
Autoimmune Diseases of the Nervous System blood
Middle Aged
Receptors, Cholinergic immunology
Adult
Aged
Myasthenia Gravis diagnosis
Myasthenia Gravis blood
Myasthenia Gravis immunology
Autoantibodies blood
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1459
- Volume :
- 271
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 38578496
- Full Text :
- https://doi.org/10.1007/s00415-024-12317-0