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The PLA 2 inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA 2 from honeybee venom.
The PLA 2 inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA 2 from honeybee venom.
- Source :
-
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 May 06; Vol. 242, pp. 107711. Date of Electronic Publication: 2024 Apr 05. - Publication Year :
- 2024
-
Abstract
- Crotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A <subscript>2</subscript> (sPLA <subscript>2</subscript> ) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA <subscript>2</subscript> from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-3150
- Volume :
- 242
- Database :
- MEDLINE
- Journal :
- Toxicon : official journal of the International Society on Toxinology
- Publication Type :
- Academic Journal
- Accession number :
- 38583578
- Full Text :
- https://doi.org/10.1016/j.toxicon.2024.107711