Back to Search Start Over

The PLA 2 inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA 2 from honeybee venom.

The PLA 2 inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA 2 from honeybee venom.

Authors :
Ortolani PL
Campos PC
Fortes-Dias CL
Source :
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 May 06; Vol. 242, pp. 107711. Date of Electronic Publication: 2024 Apr 05.
Publication Year :
2024

Abstract

Crotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A <subscript>2</subscript> (sPLA <subscript>2</subscript> ) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA <subscript>2</subscript> from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-3150
Volume :
242
Database :
MEDLINE
Journal :
Toxicon : official journal of the International Society on Toxinology
Publication Type :
Academic Journal
Accession number :
38583578
Full Text :
https://doi.org/10.1016/j.toxicon.2024.107711