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Association between low MCV in early pregnancy and perinatal mental health in the Japan Environment and Children's Study and the possible effect of iron deficiency.
- Source :
-
Journal of affective disorders [J Affect Disord] 2024 Jul 01; Vol. 356, pp. 34-40. Date of Electronic Publication: 2024 Apr 05. - Publication Year :
- 2024
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Abstract
- Background: Postpartum anemia and iron deficiency are associated with postpartum depression. This study investigated the association between a low mean corpuscular volume (MCV) without anemia (which implies early-stage iron deficiency) in early pregnancy and perinatal mental health outcomes.<br />Methods: The fixed data from the Japan Environment and Children's Study (JECS), a Japanese nationwide birth cohort, were used. Perinatal mental health was assessed using the Kessler 6-item psychological distress scale (K6) in mid-pregnancy and the Edinburgh Postnatal Depression Scale (EPDS) at 1- and 6-months postpartum.<br />Results: Among the 3635 women with MCVs <85 fL in early pregnancy, the proportions of women with K6 scores ≥13 in mid-pregnancy and EPDS scores ≥9 at 1- and 6-months postpartum were 2.7 %, 12.8 %, and 9.9 %, respectively, compared with the 33,242 women with MCVs ≥85 fL at 1.9 %, 11.9 %, and 9.0 %, respectively. Multivariate logistic regression models showed that an MCV <85 in early pregnancy was associated with a K6 score ≥ 13 in mid-pregnancy and an EPDS score ≥ 9 at 1- and 6-months postpartum (adjusted odds ratio (95 % confidence interval): 1.48 (1.16-1.87), 1.14 (1.01-1.28), and 1.09 (0.95-1.24), respectively).<br />Limitations: Low MCV values do not necessarily represent iron deficiency. Ferritin, currently the best indicator of iron deficiency, was not measured in the JECS.<br />Conclusions: This study results suggest that a low MCV without anemia in early pregnancy is associated with a slightly increased risk of perinatal mental health deterioration.<br />Competing Interests: Declaration of competing interest None.<br /> (Copyright © 2024. Published by Elsevier B.V.)
- Subjects :
- Humans
Female
Pregnancy
Japan epidemiology
Adult
Anemia, Iron-Deficiency epidemiology
Anemia, Iron-Deficiency blood
Mental Health statistics & numerical data
Iron Deficiencies
Pregnancy Complications epidemiology
Pregnancy Complications blood
Cohort Studies
Postpartum Period blood
Postpartum Period psychology
Depression, Postpartum blood
Depression, Postpartum epidemiology
Erythrocyte Indices
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2517
- Volume :
- 356
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 38583601
- Full Text :
- https://doi.org/10.1016/j.jad.2024.04.013