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Alumina inorganic molecularly imprinted polymer modified multi-walled carbon nanotubes for uric acid detection in sweat.
- Source :
-
Mikrochimica acta [Mikrochim Acta] 2024 Apr 08; Vol. 191 (5), pp. 247. Date of Electronic Publication: 2024 Apr 08. - Publication Year :
- 2024
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Abstract
- Alumina inorganic molecularly imprinted polymer (MIP) modified multi-walled carbon nanotubes (MWCNTs) on a glassy carbon electrode (MWCNTs-Al <subscript>2</subscript> O <subscript>3</subscript> -MIP/GCE) was firstly designed and fabricated by one-step electro deposition technique for the detection of uric acid (UA) in sweat. The UA templates were embedded within the inorganic MIP by co-deposition with Al <subscript>2</subscript> O <subscript>3</subscript> . Through the evaluation of morphology and structure by Field Emission Scanning Electron Microscope (SEM), Energy Dispersive X-ray Spectroscopy (EDS), X-ray Photoelectron Spectroscopy (XPS) and Transmission Electron Microscopy (TEM), it was verified that the specific recognition sites can be fabricated in the electrodeposited Al <subscript>2</subscript> O <subscript>3</subscript> molecular imprinted layer. Due to the high selectivity of molecular imprinting holes, the MWCNTs-Al <subscript>2</subscript> O <subscript>3</subscript> -MIP/GCE electrode demonstrated an impressive imprinting factor of approximately 2.338 compared to the non-molecularly imprinted glassy carbon electrode (MWCNTs-Al <subscript>2</subscript> O <subscript>3</subscript> -NIP/GCE) toward uric acid detection. Moreover, it exhibited a remarkable limit of detection (LOD) of 50 nM for UA with wide detection range from 50 nM to 600 μM. The MWCNTs-Al <subscript>2</subscript> O <subscript>3</subscript> -MIP/GCE electrode also showed strong interference resistance against common substances found in sweat. These results highlight the excellent interference resistance and selectivity of MWCNTs-Al <subscript>2</subscript> O <subscript>3</subscript> -MIP/GCE sensor, positioning it as a novel sensing platform for non-invasive uric acid detection in human sweat.<br /> (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Details
- Language :
- English
- ISSN :
- 1436-5073
- Volume :
- 191
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Mikrochimica acta
- Publication Type :
- Academic Journal
- Accession number :
- 38587580
- Full Text :
- https://doi.org/10.1007/s00604-024-06316-1