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pH-Triggered Transformable Peptide Nanocarriers Extend Drug Retention for Breast Cancer Combination Therapy.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2024 Jul; Vol. 13 (18), pp. e2400031. Date of Electronic Publication: 2024 Apr 15. - Publication Year :
- 2024
-
Abstract
- Increasing the penetration and accumulation of antitumor drugs at the tumor site are crucial in chemotherapy. Smaller drug-loaded nanoparticles (NPs) typically exhibit increased tumor penetration and more effective permeation through the nuclear membrane, whereas larger drug-loaded NPs show extended retention at the tumor site. In addition, cancer stem cells (CSCs) have unlimited proliferative potential and are crucial for the onset, progression, and metastasis of cancer. Therefore, a drug-loaded amphiphilic peptide, DDP- and ATRA-loaded Pep1 (DA/Pep1), is designed that self-assembles into spherical NPs upon the encapsulation of cis-diamminedichloroplatinum (DDP) and all-trans retinoic acid (ATRA). In an acidic environment, DA/Pep1 transforms into aggregates containing sheet-like structures, which significantly increases drug accumulation at the tumor site, thereby increasing antitumor effects and inhibiting metastasis. Moreover, although DDP treatment can increase the number of CSCs present, ATRA can induce the differentiation of CSCs in breast cancer to increase the therapeutic effect of DDP. In conclusion, this peptide nanodelivery system that transforms in response to the acidic tumor microenvironment is an extremely promising nanoplatform that suggests a new idea for the combined treatment of tumors.<br /> (© 2024 Wiley‐VCH GmbH.)
- Subjects :
- Female
Hydrogen-Ion Concentration
Humans
Animals
Drug Carriers chemistry
Cell Line, Tumor
Mice
Neoplastic Stem Cells drug effects
Neoplastic Stem Cells metabolism
Cisplatin chemistry
Cisplatin pharmacology
Cisplatin pharmacokinetics
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Mice, Inbred BALB C
Breast Neoplasms drug therapy
Breast Neoplasms pathology
Breast Neoplasms metabolism
Peptides chemistry
Nanoparticles chemistry
Tretinoin chemistry
Tretinoin pharmacology
Tretinoin pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 13
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 38588449
- Full Text :
- https://doi.org/10.1002/adhm.202400031