ODF3B affects the proliferation and apoptosis of glioma via the JAK/STAT pathway.

Authors :: Luan XZ
Yuan SX
Chen XJ
Zhou YR
Tang H
Li JQ
Jiang G
Yang LX
Luo MW
Tian JJ
Wen YQ
Zhang WY
Chen LG
Xiang W
Zhou J
Source :: American journal of cancer research [Am J Cancer Res] 2024 Mar 15; Vol. 14 (3), pp. 1419-1432. Date of Electronic Publication: 2024 Mar 15 (Print Publication: 2024).
Publication Year :: 2024
Abstract: The pathogenesis of glioma has remained unclear. In this study, it was found that high expression of the outer dense fibers of sperm tail 3B (ODF3B) in gliomas was positively correlated with the grade of glioma. The higher the grade, the worse the prognosis. ODF3B is closely related to the growth and apoptosis of glioma. In terms of mechanism, ODF3B was found to affect the proliferation and apoptosis of glioma through the JAK1 and JAK2/STAT3 pathways. ODF3B was also found to affect the growth and apoptosis of glioma in vivo . We conclude that ODF3B affects glioma proliferation and apoptosis via the JAK/STAT pathway and is a potential therapeutic target.<br />Competing Interests: None.<br /> (AJCR Copyright © 2024.)

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