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[Phase II study with methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) in hematological malignancies].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 1985 Jun; Vol. 12 (6), pp. 1253-9. - Publication Year :
- 1985
-
Abstract
- Forty-two cases of hematological malignancy (18 cases of CML, three cases of polycythemia vera, 10 cases of malignant lymphoma and 11 cases of multiple myeloma) were treated with MCNU. The results obtained were as follows. MCNU was markedly effective on CML cases, being especially useful during the chronic phase, and a partial remission was observed in one of three patients with CML blastic crisis. A good response was observed in all cases with polycythemia vera. In some cases of malignant lymphoma, a fair response was observed. No response was observed in any of the cases of multiple myeloma. Myelosuppression was a major side effect of MCNU, but other side effects other than melena were not severe.
- Subjects :
- Adult
Aged
Antineoplastic Agents administration & dosage
Drug Administration Schedule
Drug Evaluation
Female
Humans
Leukemia, Myeloid pathology
Male
Middle Aged
Nitrosourea Compounds administration & dosage
Polycythemia drug therapy
Antineoplastic Agents therapeutic use
Leukemia, Myeloid drug therapy
Lymphoma drug therapy
Multiple Myeloma drug therapy
Nitrosourea Compounds therapeutic use
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 12
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 3859250