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PTSA-induced synthesis, in silico and nano study of novel ethylquinolin-thiazolo-triazole in cervical cancer.
- Source :
-
Future medicinal chemistry [Future Med Chem] 2024; Vol. 16 (8), pp. 751-767. Date of Electronic Publication: 2024 Apr 10. - Publication Year :
- 2024
-
Abstract
- Aim: p-Toluenesulfonic acid-(PTSA) and grinding-induced novel synthesis of ethylquinolin-thiazolo-triazole derivatives was performed using green chemistry. Materials & methods: Development of a nanoconjugate drug-delivery system of ethylquinolin-thiazolo-triazole was carried out with D-α-tocopheryl polyethylene glycol succinate (TPGS) and the formulation was further characterized by transmission electron microscopy, atomic force microscopy, dynamic light scattering and in vitro drug release assay. The effect of 3a nanoparticles was assessed against a cervical cancer cell line (HeLa) through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the effect on apoptosis was determined. Results & discussion: The 3a nanoparticles triggered the apoptotic mode of cell death after increasing the intracellular reactive oxygen level by enhancing cellular uptake of micelles. Furthermore, in silico studies revealed higher absorption, distribution, metabolism, elimination and toxicity properties and bioavailability of the enzyme tyrosine protein kinase. Conclusion: The 3a nanoparticles enhanced the therapeutic potential and have higher potential for targeted drug delivery against cervical cancer.
- Subjects :
- Humans
Female
HeLa Cells
Thiazoles chemistry
Thiazoles pharmacology
Thiazoles chemical synthesis
Drug Liberation
Reactive Oxygen Species metabolism
Molecular Structure
Computer Simulation
Drug Screening Assays, Antitumor
Drug Carriers chemistry
Drug Carriers chemical synthesis
Vitamin E
Uterine Cervical Neoplasms drug therapy
Uterine Cervical Neoplasms pathology
Uterine Cervical Neoplasms metabolism
Nanoparticles chemistry
Antineoplastic Agents pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents chemical synthesis
Triazoles chemistry
Triazoles pharmacology
Triazoles chemical synthesis
Apoptosis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1756-8927
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Future medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38596902
- Full Text :
- https://doi.org/10.4155/fmc-2023-0344