A cubic DNA nanocage probe for in situ analysis of miRNA-10b in tumor-derived extracellular vesicles.

Authors :: Sun X
Chen Y
Li H
Xing W
Chen M
Wang J
Ye L
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Apr 30; Vol. 60 (36), pp. 4777-4780. Date of Electronic Publication: 2024 Apr 30.
Publication Year :: 2024
Abstract: A cubic DNA nanocage probe is able to enter EVs derived from MDA-MB-231 cells and react with miRNA-10b. The probe-loaded EVs were employed to monitor the process of entry of miRNA-10b into MCF-10A cells, allowing visualization of EV-mediated intercellular communication of miRNA-10b between the cancer cells.

Subjects :: Humans
Cell Line, Tumor
DNA Probes chemistry
Nanostructures chemistry
MicroRNAs analysis
MicroRNAs metabolism
Extracellular Vesicles chemistry
Extracellular Vesicles metabolism

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