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Sex differences orchestrated by androgens at single-cell resolution.
- Source :
-
Nature [Nature] 2024 May; Vol. 629 (8010), pp. 193-200. Date of Electronic Publication: 2024 Apr 10. - Publication Year :
- 2024
-
Abstract
- Sex differences in mammalian complex traits are prevalent and are intimately associated with androgens <superscript>1-7</superscript> . However, a molecular and cellular profile of sex differences and their modulation by androgens is still lacking. Here we constructed a high-dimensional single-cell transcriptomic atlas comprising over 2.3 million cells from 17 tissues in Mus musculus and explored the effects of sex and androgens on the molecular programs and cellular populations. In particular, we found that sex-biased immune gene expression and immune cell populations, such as group 2 innate lymphoid cells, were modulated by androgens. Integration with the UK Biobank dataset revealed potential cellular targets and risk gene enrichment in antigen presentation for sex-biased diseases. This study lays the groundwork for understanding the sex differences orchestrated by androgens and provides important evidence for targeting the androgen pathway as a broad therapeutic strategy for sex-biased diseases.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
- Subjects :
- Animals
Female
Humans
Male
Mice
Antigen Presentation drug effects
Antigen Presentation genetics
Immunity, Innate
Lymphocytes metabolism
Lymphocytes cytology
Lymphocytes immunology
Lymphocytes drug effects
Mice, Inbred C57BL
UK Biobank
Androgens metabolism
Androgens pharmacology
Sex Characteristics
Single-Cell Analysis
Transcriptome drug effects
Transcriptome genetics
Cells drug effects
Cells immunology
Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 629
- Issue :
- 8010
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 38600383
- Full Text :
- https://doi.org/10.1038/s41586-024-07291-6