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Nephro-protective effects of alpha-lipoic acid in type I diabetes.
- Source :
-
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2024 Apr; Vol. 38 (4), pp. e23712. - Publication Year :
- 2024
-
Abstract
- Type 1 diabetes (T1D) is an insulin-dependent autoimmune condition. Short chain fatty acids (SCFAs) are volatile fatty acids with 1-6 carbon atoms that influence glucose storage in the body and can reduce appetite, potentially decreasing T1D risk. Alpha-lipoic acid (α-LA), a type of SCFA, has previously been used to treat diabetic neuropathy and inflammation due to its antioxidant properties. This study aims to assess α-LA's protective effects against T1D and associated kidney damage in rats induced with streptozotocin. Diabetic rats were treated with α-LA orally for 15 days, resulting in improved blood glucose (56% decrease) and kidney function markers like blood urea nitrogen, creatinine and uric acid. α-LA also showed significant antioxidant effects by decreasing LPO as well as improving activities of antioxidant enzymes like superoxide dismutase, catalase and glutathione-S transferase and alleviated kidney damage caused by diabetes. Docking experiments suggest that α-LA may regulate diabetes-related changes at the epigenetic level through interactions with the SIRT1 protein, indicating its potential as a target for future antidiabetic drug development.<br /> (© 2024 Wiley Periodicals LLC.)
- Subjects :
- Rats
Animals
Antioxidants metabolism
Rats, Wistar
Lipid Peroxidation
Catalase metabolism
Blood Glucose metabolism
Superoxide Dismutase metabolism
Oxidative Stress
Thioctic Acid pharmacology
Thioctic Acid therapeutic use
Diabetes Mellitus, Type 1 drug therapy
Diabetes Mellitus, Experimental metabolism
Kidney Diseases
Subjects
Details
- Language :
- English
- ISSN :
- 1099-0461
- Volume :
- 38
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of biochemical and molecular toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 38602238
- Full Text :
- https://doi.org/10.1002/jbt.23712