Back to Search
Start Over
Role of nitric oxide and signaling pathways modulating the stimulatory effect of snake venom secretory PLA 2 S on non-opsonized zymosan phagocytosis by macrophages.
- Source :
-
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 May 28; Vol. 243, pp. 107716. Date of Electronic Publication: 2024 Apr 16. - Publication Year :
- 2024
-
Abstract
- The phagocytic activity of macrophages activated with MT-II, a Lys-49 PLA <subscript>2</subscript> homolog, and MT-III, an Asp-49 PLA <subscript>2</subscript> , from Bothrops asper snake venom, was investigated in this study using a pharmacological approach. Stimulating thioglycollate-elicited macrophages with both venom components enhanced their ability to phagocytose non-opsonized zymosan particles. MT-II and MT-III-induced phagocytosis was drastically inhibited by pretreating cells with L-NAME, aminoguanidine or L-NIL, cNOS or iNOS inhibitors, or with ODQ (sGC inhibitor) or Rp-cGMPS (PKG inhibitor). These results indicate that the NO/sGC/GMP/PKG pathway plays an essential role in the β-glucan-mediated phagocytosis induced in macrophages by these venom-secretory PLA <subscript>2</subscript> s.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-3150
- Volume :
- 243
- Database :
- MEDLINE
- Journal :
- Toxicon : official journal of the International Society on Toxinology
- Publication Type :
- Academic Journal
- Accession number :
- 38614247
- Full Text :
- https://doi.org/10.1016/j.toxicon.2024.107716