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An exosomal approach for oral delivery of resveratrol: Implications for inflammatory bowel disease treatment in rat model.
- Source :
-
Life sciences [Life Sci] 2024 Jun 01; Vol. 346, pp. 122638. Date of Electronic Publication: 2024 Apr 12. - Publication Year :
- 2024
-
Abstract
- Aims: Resveratrol (RSV) is a polyphenolic substance found in numerous natural products. Despite the wide range of therapeutic activities, including antioxidant and anti-inflammatory effects, the poor pharmacokinetic characteristics decrease the RSV bioavailability following oral administration. Milk-derived exosomes (MEXOs), as a class of natural nanocarriers, are promising candidates for oral drug delivery approaches.<br />Main Methods: The current study developed RSV-loaded MEXOs to enhance the RSV oral bioavailability, introducing a suitable exosomal formulation for suppressing colon inflammation in acetic acid-induced rat models.<br />Key Findings: The results showed a remarkable encapsulation efficiency of 83.33 %. The in vitro release profile demonstrated a good retaining capability in acidic conditions (pH 1.2) and a considerable release in a simulated duodenal environment (pH 6.8). According to the permeability study, encapsulation of RSV improved its transportation across the Caco-2 monolayer. Moreover, the in vivo and histological analysis results proved that the RSV-MEXOs formulation successfully alleviates the inflammation in colitis rat models and effectively relieves the colitis.<br />Significance: Our findings suggest that MEXOs should be of great attention as promising oral drug delivery vehicles for further clinical evaluations.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Rats
Administration, Oral
Caco-2 Cells
Humans
Male
Drug Delivery Systems methods
Rats, Sprague-Dawley
Biological Availability
Milk
Colitis drug therapy
Colitis chemically induced
Colitis pathology
Resveratrol administration & dosage
Resveratrol pharmacology
Resveratrol pharmacokinetics
Exosomes metabolism
Inflammatory Bowel Diseases drug therapy
Disease Models, Animal
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0631
- Volume :
- 346
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38614294
- Full Text :
- https://doi.org/10.1016/j.lfs.2024.122638