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Systemic inflammation score as a predictor of death within one year after esophagectomy.
- Source :
-
Esophagus : official journal of the Japan Esophageal Society [Esophagus] 2024 Jul; Vol. 21 (3), pp. 336-347. Date of Electronic Publication: 2024 Apr 16. - Publication Year :
- 2024
-
Abstract
- Background: After radical resection for esophageal cancer, death within 1 year of surgery can occur due both to recurrence and to other diseases, even after postoperative complications have been overcome. This study identified risk factors for early death within 1 year of esophagectomy for reasons other than death in hospital in patients undergoing esophagectomy for esophageal cancer or esophagogastric junction cancer.<br />Methods: We reviewed 366 patients who underwent esophagectomy without adjuvant treatment between January 2009 and July 2022 for thoracic esophageal cancer or esophagogastric junction cancer. Patients who died within 1 year excluding in-hospital death were compared with those who did not. Multivariable logistic regression analysis was used to identify predictors of death within 1 year after surgery.<br />Results: Death within 1 year occurred in 32 of 366 patients, 24 from primary disease and 8 from other diseases. Deaths within 1 year were significantly older than the other cases, had significantly lower % vital capacity (%VC), and occurred significantly more often in cases in advanced stages of disease. In a multivariable analysis, a systemic inflammation score (SIS) based on serum albumin level and lymphocyte-to-monocyte ratio was identified as an independent predictor of death within 1 year. As SIS increased, %VC decreased significantly, and CRP level and neutrophil-lymphocyte ratio increased significantly. There was no relationship between SIS and pN. Death within 1 year increased as SIS increased (pā=ā0.001 for trend).<br />Conclusion: SIS assessment undertaken before beginning esophageal cancer treatment is a useful predictor of death within 1 year of surgery.<br /> (© 2024. The Author(s), under exclusive licence to The Author(s) under exclusive licence to The Japan Esophageal Society.)
- Subjects :
- Humans
Male
Female
Aged
Middle Aged
Risk Factors
Postoperative Complications mortality
Retrospective Studies
Lymphocytes
Serum Albumin analysis
Serum Albumin metabolism
Neutrophils
Aged, 80 and over
Monocytes
Esophagectomy adverse effects
Esophageal Neoplasms surgery
Esophageal Neoplasms mortality
Esophageal Neoplasms pathology
Inflammation blood
Esophagogastric Junction pathology
Esophagogastric Junction surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1612-9067
- Volume :
- 21
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Esophagus : official journal of the Japan Esophageal Society
- Publication Type :
- Academic Journal
- Accession number :
- 38625663
- Full Text :
- https://doi.org/10.1007/s10388-024-01059-7