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Transmission of bla NDM in Enterobacteriaceae among animals, food and human.

Authors :
Fu B
Xu J
Yin D
Sun C
Liu D
Zhai W
Bai R
Cao Y
Zhang Q
Ma S
Walsh TR
Hu F
Wang Y
Wu C
Shen J
Source :
Emerging microbes & infections [Emerg Microbes Infect] 2024 Dec; Vol. 13 (1), pp. 2337678. Date of Electronic Publication: 2024 Apr 20.
Publication Year :
2024

Abstract

Despite carbapenems not being used in animals, carbapenem-resistant Enterobacterales (CRE), particularly New Delhi metallo-β-lactamase-producing CRE (NDM-CRE), are prevalent in livestock. Concurrently, the incidence of human infections caused by NDM-CRE is rising, particularly in children. Although a positive association between livestock production and human NDM-CRE infections at the national level was identified, the evidence of direct transmission of NDM originating from livestock to humans remains largely unknown. Here, we conducted a cross-sectional study in Chengdu, Sichuan Province, to examine the prevalence of NDM-CRE in chickens and pigs along the breeding-slaughtering-retail chains, in pork in cafeterias of schools, and in colonizations and infections from children's hospital and examined the correlation of NDM-CRE among animals, foods and humans. Overall, the bla <subscript>NDM</subscript> increases gradually along the chicken and pig breeding (4.70%/2.0%) -slaughtering (7.60%/22.40%) -retail (65.56%/34.26%) chains. The slaughterhouse has become a hotspot for cross-contamination and amplifier of bla <subscript>NDM</subscript> . Notably, 63.11% of pork from the school cafeteria was positive for bla <subscript>NDM</subscript> . The prevalence of bla <subscript>NDM</subscript> in intestinal and infection samples from children's hospitals was 21.68% and 19.80%, respectively. whole genome sequencing (WGS) analysis revealed the sporadic, not large-scale, clonal spread of NDM-CRE along the chicken and pig breeding-slaughtering-retail chain, with further spreading via IncX3- bla <subscript>NDM</subscript> plasmid within each stage of whole chains. Clonal transmission of NDM-CRE is predominant in children's hospitals. The IncX3- bla <subscript>NDM</subscript> plasmid was highly prevalent among animals and humans and accounted for 57.7% of Escherichia coli and 91.3% of Klebsiella pneumoniae . Attention should be directed towards the IncX3 plasmid to control the transmission of bla <subscript>NDM</subscript> between animals and humans.

Details

Language :
English
ISSN :
2222-1751
Volume :
13
Issue :
1
Database :
MEDLINE
Journal :
Emerging microbes & infections
Publication Type :
Academic Journal
Accession number :
38629492
Full Text :
https://doi.org/10.1080/22221751.2024.2337678