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Isoflavones isolated from the fruits of Ficus altissima and their anti-proliferative activities.
- Source :
-
Fitoterapia [Fitoterapia] 2024 Jun; Vol. 175, pp. 105966. Date of Electronic Publication: 2024 Apr 16. - Publication Year :
- 2024
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Abstract
- Ficus altissima, also known as lofty fig, is a monoecious plant from the Moraceae family commonly found in southern China. In this study, we isolated and identified one new isoflavone (1), three new hydroxycoumaronochromones (2a, 2b and 3a) and 12 known compounds from the fruits of F. altissima. Their chemical structures were determined using spectroscopic analysis methods. We also tested all the isolated compounds for their anti-proliferative activities against eight human tumour cell lines (A-549, AGS, K562, K562/ADR, HepG2, HeLa, SPC-A-1 and CNE2) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Our experiments showed that compound 6 exhibited obvious anti-proliferative activity against the K562 cell line with an IC <subscript>50</subscript> value of 1.55 μM. Additionally, compounds 8 and 9 showed significant anti-proliferative activities against the AGS and K562 cell lines, respectively. Moreover, compound 6 induced apoptosis in K562 cells through the caspase family signalling pathway.<br />Competing Interests: Declaration of competing interest The authors declare no competing financial interest.<br /> (Copyright © 2023. Published by Elsevier B.V.)
- Subjects :
- Humans
Molecular Structure
Cell Line, Tumor
China
Phytochemicals pharmacology
Phytochemicals isolation & purification
Cell Proliferation drug effects
K562 Cells
Ficus chemistry
Fruit chemistry
Isoflavones pharmacology
Isoflavones isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Antineoplastic Agents, Phytogenic isolation & purification
Apoptosis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 175
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 38631600
- Full Text :
- https://doi.org/10.1016/j.fitote.2024.105966