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Frequency of an intrathecal IgM synthesis and MRZ reaction in children with MS.
- Source :
-
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society [Eur J Paediatr Neurol] 2024 May; Vol. 50, pp. 51-56. Date of Electronic Publication: 2024 Apr 16. - Publication Year :
- 2024
-
Abstract
- Background: Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the CNS. An intrathecal IgM synthesis is associated with a more rapid progression of MS and the intrathecal immune response to measles -, rubella -and varicella zoster virus (MRZR) which, if present, increases the likelihood of a diagnosis of MS in adults.<br />Objective: To evaluate the frequency of an intrathecal IgM synthesis and MRZR in children with MS. MethodsChildren with MS and a data set including clinical and treatment history, MRI at onset, in addition to a CSF analysis, and determination of antibody index (AI) of measles, rubella, and zoster antibodies, were eligible. The presence of an intrathecal IgM synthesis and/or a positive MRZ reaction were compared to biomarkers of a more progressive disease course.<br />Results: In 75 children with MS, OCBs were present in 93.3 %). 49,2 % experienced their first relapse within 6 months. 50.7 % had a total lesion load of more than 10 lesions in the first brain MRI. Spinal lesions were identified in 64 %. 23.5 % had a positive MRZR and 40.3 % an intrathecal IgM synthesis. No significant associations were detected between the presence of an intrathecal IgM synthesis and MRZR and parameters including the relapse rate in the first two years.<br />Conclusion: An intrathecal IgM synthesis and a positive MRZR are found in a subset of MS children but are not associated with markers associated with a poor prognosis.<br /> (© 2024 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Male
Child
Female
Adolescent
Herpesvirus 3, Human immunology
Antibodies, Viral cerebrospinal fluid
Antibodies, Viral blood
Child, Preschool
Measles virus immunology
Rubella virus immunology
Disease Progression
Brain diagnostic imaging
Biomarkers cerebrospinal fluid
Immunoglobulin M cerebrospinal fluid
Multiple Sclerosis diagnostic imaging
Multiple Sclerosis immunology
Multiple Sclerosis cerebrospinal fluid
Magnetic Resonance Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2130
- Volume :
- 50
- Database :
- MEDLINE
- Journal :
- European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
- Publication Type :
- Academic Journal
- Accession number :
- 38636242
- Full Text :
- https://doi.org/10.1016/j.ejpn.2024.04.005