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Phage-antibiotic combinations to control Pseudomonas aeruginosa-Candida two-species biofilms.
- Source :
-
Scientific reports [Sci Rep] 2024 Apr 23; Vol. 14 (1), pp. 9354. Date of Electronic Publication: 2024 Apr 23. - Publication Year :
- 2024
-
Abstract
- Phage-antibiotic combinations to treat bacterial infections are gaining increased attention due to the synergistic effects often observed when applying both components together. Most studies however focus on a single pathogen, although in many clinical cases multiple species are present at the site of infection. The aim of this study was to investigate the anti-biofilm activity of phage-antibiotic/antifungal combinations on single- and dual-species biofilms formed by P. aeruginosa and the fungal pathogen Candida albicans. The Pseudomonas phage Motto in combination with ciprofloxacin had significant anti-biofilm activity. We then compared biofilms formed by P. aeruginosa alone with the dual-species biofilms formed by bacteria and C. albicans. Here, we found that the phage together with the antifungal fluconazole was active against 6-h-old dual-species biofilms but showed only negligible activity against 24-h-old biofilms. This study lays the first foundation for potential therapeutic approaches to treat co-infections caused by bacteria and fungi using phage-antibiotic combinations.<br /> (© 2024. The Author(s).)
- Subjects :
- Fluconazole pharmacology
Microbial Sensitivity Tests
Biofilms drug effects
Biofilms growth & development
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa physiology
Pseudomonas aeruginosa virology
Antifungal Agents pharmacology
Anti-Bacterial Agents pharmacology
Pseudomonas Phages physiology
Candida albicans drug effects
Candida albicans physiology
Ciprofloxacin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 38653744
- Full Text :
- https://doi.org/10.1038/s41598-024-59444-2