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Mitochondrial fractions located in the cytoplasmic and peridroplet areas of white adipocytes have distinct roles.
- Source :
-
FEBS letters [FEBS Lett] 2024 Jul; Vol. 598 (14), pp. 1753-1768. Date of Electronic Publication: 2024 Apr 24. - Publication Year :
- 2024
-
Abstract
- The role of mitochondria in white adipocytes (WAs) has not been fully explored. A recent study revealed that brown adipocytes contain functionally distinct mitochondrial fractions, cytoplasmic mitochondria, and peridroplet mitochondria. However, it is not known whether such a functional division of mitochondria exists in WA. Herein, we observed that mitochondria could be imaged and mitochondrial DNA and protein detected in pellets obtained from the cytoplasmic layer and oil layer of WAs after centrifugation. The mitochondria in each fraction were designated as cytoplasmic mitochondria (CMw) and peridroplet mitochondria (PDMw) in WAs, respectively. CMw had higher β-oxidation activity than PDMw, and PDMw was associated with diacylglycerol acyltransferase 2. Therefore, CMw may be involved in β-oxidation and PDMw in droplet expansion in WAs.<br /> (© 2024 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
- Subjects :
- Animals
DNA, Mitochondrial metabolism
DNA, Mitochondrial genetics
Mice
Oxidation-Reduction
Diacylglycerol O-Acyltransferase metabolism
Diacylglycerol O-Acyltransferase genetics
Mitochondrial Proteins metabolism
Mitochondrial Proteins genetics
Mitochondria metabolism
Mitochondria genetics
Cytoplasm metabolism
Adipocytes, White metabolism
Adipocytes, White cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3468
- Volume :
- 598
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Editorial & Opinion
- Accession number :
- 38658180
- Full Text :
- https://doi.org/10.1002/1873-3468.14877