Back to Search
Start Over
Design, synthesis, and evaluation of novel arecoline-linked amino acid derivatives for insecticidal and antifungal activities.
- Source :
-
Scientific reports [Sci Rep] 2024 Apr 24; Vol. 14 (1), pp. 9392. Date of Electronic Publication: 2024 Apr 24. - Publication Year :
- 2024
-
Abstract
- A series of arecoline derivatives with amino acid moieties were designed and synthesised using an acylamide condensation strategy, taking arecoline as the foundational structure. The insecticidal efficacy of these compounds against Aphis craccivora and Tetranychus cinnabarinus was evaluated. Notably, derivatives 3h and 3i demonstrated superior insecticidal activity compared with arecoline. Additionally, 3h and 3i showed good fungicidal effectiveness against two types of plant fungi. Moreover, molecular docking analyses suggested that 3h and 3i could affect the nervous systems of A. craccivora and T. cinnabarinus by binding to neuronal nicotinic acetylcholine receptors. These findings suggest that compounds 3h and 3i represent promising leads for further development in insecticide and fungicide research.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Aphids drug effects
Tetranychidae drug effects
Structure-Activity Relationship
Receptors, Nicotinic metabolism
Receptors, Nicotinic chemistry
Microbial Sensitivity Tests
Insecticides pharmacology
Insecticides chemical synthesis
Insecticides chemistry
Antifungal Agents pharmacology
Antifungal Agents chemical synthesis
Antifungal Agents chemistry
Molecular Docking Simulation
Amino Acids chemistry
Drug Design
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 38658769
- Full Text :
- https://doi.org/10.1038/s41598-024-60053-2