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[Basic and clinical studies of ceftizoxime suppositories in the pediatric field].
- Source :
-
The Japanese journal of antibiotics [Jpn J Antibiot] 1985 Oct; Vol. 38 (10), pp. 2925-31. - Publication Year :
- 1985
-
Abstract
- A bacteriological and clinical study of ceftizoxime suppositories (CZX-S) let to the following results. The CZX serum concentration 10 minutes after insertion of one 250 mg suppository (i.e. 5.7-15.2 mg CZX per kg body weight) ranged from 1.64 to 6.53 micrograms/ml (average: 4.41 micrograms/ml). In one child the concentration 7 minutes after insertion was 4.13 micrograms/ml. Therapeutic responsiveness was recorded as "effective" in 8 (88.9%) of the 9 children who were broken down into 6 with tonsillitis, 1 with pharyngitis, and 2 with UTI. Bacteriological studies conducted in 5 children have confirmed eradication in 4 children, one of whom showing appearance of another strain. The rate of discharge of the suppository within 10 minutes after insertion was 20.4%. Reddening and erosion of the anus were observed in 1 child.
- Subjects :
- Adolescent
Bacteria drug effects
Cefotaxime administration & dosage
Cefotaxime metabolism
Cefotaxime therapeutic use
Ceftizoxime
Child
Child, Preschool
Drug Evaluation
Drug Resistance, Microbial
Female
Humans
Infant
Kinetics
Male
Suppositories
Bacterial Infections drug therapy
Cefotaxime analogs & derivatives
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0368-2781
- Volume :
- 38
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Japanese journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 3866086