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[Research progress on bioinformatics in pulmonary arterial hypertension].

Authors :
Peng W
Zhang ZY
Xiao YB
Source :
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics [Zhongguo Dang Dai Er Ke Za Zhi] 2024 Apr 15; Vol. 26 (4), pp. 425-431.
Publication Year :
2024

Abstract

Pulmonary arterial hypertension (PAH) is a severe disease characterized by abnormal pulmonary vascular remodeling and increased right ventricular pressure load, posing a significant threat to patient health. While some pathological mechanisms of PAH have been revealed, the deeper mechanisms of pathogenesis remain to be elucidated. In recent years, bioinformatics has provided a powerful tool for a deeper understanding of the complex mechanisms of PAH through the integration of techniques such as multi-omics analysis, artificial intelligence, and Mendelian randomization. This review focuses on the bioinformatics methods and technologies used in PAH research, summarizing their current applications in the study of disease mechanisms, diagnosis, and prognosis assessment. Additionally, it analyzes the existing challenges faced by bioinformatics and its potential applications in the clinical and basic research fields of PAH in the future.

Details

Language :
Chinese
ISSN :
1008-8830
Volume :
26
Issue :
4
Database :
MEDLINE
Journal :
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Publication Type :
Academic Journal
Accession number :
38660909
Full Text :
https://doi.org/10.7499/j.issn.1008-8830.2310076