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Pulmonary thrombotic pulmonary hypertension managed using antithrombotic and pulmonary vasodilator treatment.
- Source :
-
Journal of veterinary internal medicine [J Vet Intern Med] 2024 Jul-Aug; Vol. 38 (4), pp. 2333-2338. Date of Electronic Publication: 2024 Apr 25. - Publication Year :
- 2024
-
Abstract
- An 8-year-old Leonberger receiving immunosuppressive treatment with clinical signs of acute dyspnea, cyanosis, and difficulty standing was referred to our institution (Day 1). Treatment including oxygen, clopidogrel, and low-molecular-weight heparin was initiated for suspected pulmonary thrombosis. However, exertional dyspnea persisted until Day 10, and increased tricuspid regurgitation velocity, pulmonary vascular resistance, and McConnell's signs also were observed. Thus, beraprost sodium was administered PO on Day 11 to treat suspected pulmonary hypertension. On Day 13, contrast-enhanced computed tomography identified extensive contrast defects in the pulmonary arteries, and IV monteplase was administered on Days 14 and 18, with marked improvement in respiratory status and exertional dyspnea on Day 20. Right ventricular function and McConnell signs also improved, and tricuspid regurgitation velocity and pulmonary vascular resistance decreased. On Day 250, echocardiography indicated further improvement in pulmonary hypertension pathophysiology. The patient was still progressing well with antithrombotic and pulmonary vasodilator treatment 400 days later.<br /> (© 2024 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)
- Subjects :
- Animals
Dogs
Dog Diseases drug therapy
Male
Epoprostenol therapeutic use
Epoprostenol analogs & derivatives
Thrombosis drug therapy
Thrombosis veterinary
Hypertension, Pulmonary drug therapy
Hypertension, Pulmonary veterinary
Fibrinolytic Agents therapeutic use
Vasodilator Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1939-1676
- Volume :
- 38
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of veterinary internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38662965
- Full Text :
- https://doi.org/10.1111/jvim.17089